Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13725004 | 0.64 | KDM4E (0.36) | KDM4EALDH1A1TDP1 | |
| SCHEMBL577002 | 0.53 | — | — | |
| SCHEMBL576660 | 0.53 | — | — | |
| SCHEMBL7759323 | 0.53 | — | — | |
| SCHEMBL2338091 | 0.53 | — | — | |
| SCHEMBL23150769 | 0.53 | — | — | |
| SCHEMBL7204681 | 0.53 | — | — | |
| SCHEMBL10591665 | 0.53 | — | — | |
| SCHEMBL810089 | 0.50 | — | — | |
| SCHEMBL11670206 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002512-B1 | IMINO-BRIDGED BENZOCYCLOHEPTAPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF | MERCK & CO. INC. (US) | 1984-02-22 | — | — | EP | claimed |
| EP-0011206-B1 | 9,10-DIHYDRO-4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHEN-4,9 IMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1983-01-19 | — | — | EP | claimed |
| EP-0011206-A1 | 9,10-Dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thiophen-4,9 imines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1980-05-28 | — | — | EP | claimed |
| EP-0002512-A1 | Imino-bridged benzocycloheptapyridines, process for their preparation and pharmaceutical composition thereof | MERCK & CO. INC. (US) | 1979-06-27 | — | — | EP | claimed |
| US-5349076-A | Method bis(trifluoromethylthio)arsine | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1994-09-20 | — | — | US | disclosed |
| US-4644011-A | LIVER AND VIEN DISORDERS | ZYMA SA (CH) | 1987-02-17 | — | — | US | disclosed |
| US-4590202-A | CARDIOTONIC, HYPOTENSIVE AGENTS; ANTIDEPRESSANTS | MERCK & CO., INC. (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0002512-B1 | IMINO-BRIDGED BENZOCYCLOHEPTAPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF | MERCK & CO. INC. (US) | 1984-02-22 | — | — | EP | disclosed |
| EP-0096007-A2 | Pharmaceutical preparations containing (+)-cyanidan-3-ol derivatives, the use thereof, novel substituted (+)-cyanidan-3-ol derivatives, and processes for producing them | Zyma SA (CH) | 1983-12-07 | — | — | EP | disclosed |
| US-4414154-A | ANXIOLYTIC, ANTIDEPRESSANT, ANTICONVULSANT, MUSCLE RELAXANTS | MERCK & CO. INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4399141-A | 5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof | MERCK & CO., INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4374838-A | USEFUL AS ANXIOLYTICS, ANTIDEPRESSANTS, ANTICONVULSANTS, MUSCLE RELAXANTS AND IN THE TREATMENT OF PARKINSONS'S DISEASE | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| US-4056536-A | CHEMICAL INTERMEDIATES | MERCK & CO., INC. (US) | 1977-11-01 | — | — | US | disclosed |
| US-4031223-A | ANTIEXTRAPYRAMIDAL, ANTIPSYCHOTIC, ENANTIOMERS, TRANQUILIZERS, ANTICHOLINERGIC | MERCK & CO., INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4031223-A | ANTIEXTRAPYRAMIDAL, ANTIPSYCHOTIC, ENANTIOMERS, TRANQUILIZERS, ANTICHOLINERGIC | MERCK & CO., INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4031222-A | ANTIEXTRAPYRAMIDAL, ANTIPSYCHOTIC, ENANTIOMERS, TRANQUILIZERS, ANTICHOLINERGIC | MERCK & CO., INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4031222-A | ANTIEXTRAPYRAMIDAL, ANTIPSYCHOTIC, ENANTIOMERS, TRANQUILIZERS, ANTICHOLINERGIC | MERCK & CO., INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4021561-A | ANTIPSYCHOTICS | MERCK & CO., INC. (US) | 1977-05-03 | — | — | US | disclosed |
| US-4020169-A | FROM ARYL IODIDE OR BROMIDE AND TRIFLUOROMETHYL THIO COPPER | MERCK & CO., INC. (US) | 1977-04-26 | — | — | US | disclosed |
| US-4020169-A | FROM ARYL IODIDE OR BROMIDE AND TRIFLUOROMETHYL THIO COPPER | MERCK & CO., INC. (US) | 1977-04-26 | — | — | US | disclosed |