Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.56 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.56 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.56 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.56 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.56 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.56 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | RAD52 | P43351 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10783842 | 1.00 | HSP90AA1 (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL4061739 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL4230451 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL4394540 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL5291635 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL5297233 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL3922589 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL5292793 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL4061049 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 | |
| SCHEMBL5291118 | 0.98 | HTT (0.56) | HSP90AA1HTTLMNARAD52SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616520-A1 | PHYTATE-ANTIMICROBIAL COMPOSITIONS IN ORAL CARE PRODUCTS. | DOW CHEMICAL CO (US) | 1994-09-28 | — | — | EP | disclosed |
| US-4100099-A | Quaternary salt-polyamine inhibitor for sour gas conditioning solutions | THE DOW CHEMICAL COMPANY (US) | 1978-07-11 | — | — | US | disclosed |