Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | GRK6 | P43250 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300684 | 1.00 | KAT2B (0.64) | KAT2BALDH1A1MAPTHCAR3GRM8 | |
| SCHEMBL9299748 | 0.96 | KAT2B (0.62) | KAT2BALDH1A1MAPTHCAR3GRM8 | |
| SCHEMBL9301798 | 0.93 | KAT2B (0.60) | KAT2BALDH1A1MAPTGRM8GRM6 | |
| SCHEMBL9301636 | 0.91 | KAT2B (0.64) | KAT2BALDH1A1MAPTHCAR3 | |
| SCHEMBL9300603 | 0.87 | KAT2B (0.46) | KAT2BHCAR3GRM8GRM4 | |
| SCHEMBL9300134 | 0.86 | SMN1; SMN2 (0.50) | KAT2BMAPTGRM8GRM4 | |
| SCHEMBL9300180 | 0.84 | KAT2B (0.65) | KAT2BALDH1A1MAPT | |
| SCHEMBL9300121 | 0.84 | KAT2B (0.65) | KAT2BALDH1A1MAPTGRK6 | |
| SCHEMBL9391236 | 0.83 | KAT2B (0.57) | KAT2BALDH1A1MAPTHCAR3GRK6 | |
| SCHEMBL9388618 | 0.81 | KAT2B (0.61) | KAT2BALDH1A1MAPTGRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994012163-A1 | 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE | ABBOTT LABORATORIES (US) | 1994-06-09 | — | — | WO | claimed |
| US-5362747-A | Promoters, inhibitors | ABBOTT LABORATORIES (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1994012163-A1 | 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE | ABBOTT LABORATORIES (US) | 1994-06-09 | — | — | WO | disclosed |