Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.78 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300434 | 0.98 | TOP2A (0.78) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9300065 | 0.94 | TOP2A (0.83) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9302060 | 0.89 | TOP2A (0.76) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9300031 | 0.88 | TOP2A (0.61) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9301432 | 0.86 | TOP2A (0.61) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9300052 | 0.85 | TOP2A (0.73) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL3983034 | 0.83 | TOP2A (0.77) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL3984609 | 0.81 | TOP2A (0.74) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9300149 | 0.81 | TOP2A (0.64) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9299772 | 0.80 | TOP2A (0.62) | TOP2ATOP2BKDM4EMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |
| US-11311625-B2 | Peptide-based multiple-drug delivery vehicle | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2022-04-26 | — | — | US | disclosed |
| US-20200069811-A1 | PEPTIDE-BASED MULTIPLE-DRUG DELIVERY VEHICLE | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2020-03-05 | — | — | US | disclosed |
| US-10478507-B2 | Peptide-based multiple-drug delivery vehicle | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2019-11-19 | — | — | US | disclosed |
| WO-2017068577-A1 | PEPTIDE-BASED MULTIPLE-DRUG DELIVERY VEHICLE | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2017-04-27 | — | — | WO | disclosed |
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11311625-B2 | Peptide-based multiple-drug delivery vehicle | VIP, NGLY1, IAPP | TOP2A 4024/4885TOP2B 3598/4885KDM4E 4095/4885 |
| US-20200069811-A1 | PEPTIDE-BASED MULTIPLE-DRUG DELIVERY VEHICLE | VIP, NGLY1, IAPP | TOP2A 4024/4885TOP2B 3598/4885KDM4E 4095/4885 |
| US-10478507-B2 | Peptide-based multiple-drug delivery vehicle | VIP, NGLY1, IAPP | TOP2A 4024/4885TOP2B 3598/4885KDM4E 4095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.