Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 10/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | LY6K | Q17RY6 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300901 | 0.89 | KDM4E (0.48) | ELANEKDM4EPOLBGLATOP2A | |
| SCHEMBL9300661 | 0.87 | TOP2A (0.47) | ELANEKDM4EPOLBGLATOP2A | |
| SCHEMBL9300791 | 0.82 | TOP2A (0.59) | ELANEKDM4EPOLBGLATOP2A | |
| SCHEMBL9299716 | 0.81 | POLB (0.43) | ELANEKDM4EPOLBGLATOP2A | |
| SCHEMBL9300635 | 0.80 | KDM4E (0.42) | ELANEKDM4EPOLBGLATOP2A | |
| SCHEMBL9300832 | 0.79 | TOP2A (0.47) | KDM4EPOLBGLATOP2ATOP2B | |
| SCHEMBL9300653 | 0.79 | POLB (0.47) | KDM4EPOLBGLATOP2ATOP2B | |
| SCHEMBL9301423 | 0.77 | KDM4E (0.46) | KDM4EPOLBGLATOP2ATOP2B | |
| SCHEMBL9301381 | 0.77 | TOP2A (0.45) | KDM4EPOLBGLATOP2ATOP2B | |
| SCHEMBL9547241 | 0.75 | TOP2A (0.51) | KDM4EPOLBGLATOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |