Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.52 |
| ▸ | HPGD | P15428 | 8/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300782 | 0.85 | KDM4E (0.71) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL9300919 | 0.81 | KDM4E (0.66) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL8196129 | 0.77 | KDM4E (0.52) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL14124198 | 0.77 | KDM4E (0.63) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL8256942 | 0.76 | KDM4E (0.51) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL25117949 | 0.74 | KDM4E (0.54) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL10617852 | 0.73 | KDM4E (0.54) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL13232457 | 0.72 | KDM4E (0.53) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL25117799 | 0.72 | KDM4E (0.50) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL1006040 | 0.71 | KDM4E (0.68) | KDM4EMAPTALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5319140-A | Antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5138066-A | Intermediates for cephalosporins with sulfur-containing oxyimino side chain | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-11 | — | — | US | disclosed |
| US-5073550-A | Bactericides | HOFFMANN-LA ROCHE INC. (US) | 1991-12-17 | — | — | US | disclosed |
| US-5036064-A | Antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1991-07-30 | — | — | US | disclosed |
| EP-0303172-A2 | Oxyimino-cephalosporins | F. HOFFMANN-LA ROCHE AG (CH) | 1989-02-15 | — | — | EP | disclosed |
| EP-0286145-A2 | 3-Heterocyclylthiomethyl cephalosporins | SANKEI PHARMACEUTICAL COMPANY LIMITED (JP) | 1988-10-12 | — | — | EP | disclosed |