Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | RAD52 | P43351 | 2/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | KDM1A | O60341 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | MITF | O75030 | 1/20 | 0.72 |
| ▸ | RECQL | P46063 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | TOP2A | P11388 | 6/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17154374 | 0.86 | KMT2A (0.76) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL9300052 | 0.86 | TOP2A (0.73) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL9300054 | 0.85 | TOP2A (0.74) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL17154400 | 0.84 | KDM1A (1.00) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL4658830 | 0.83 | KDM1A (0.67) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL9300059 | 0.82 | TOP2A (0.61) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL9299881 | 0.80 | TOP2A (0.59) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL9547337 | 0.79 | KDM4E (0.55) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL9300986 | 0.79 | POLB (0.55) | KMT2AKDM4EMAPTPOLBRAD52 | |
| SCHEMBL9300216 | 0.79 | TOP2A (0.56) | KMT2AKDM4EMAPTPOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1993023049-A1 | 3-(9-ACRIDINYLAMINO)-5-HYDROXYMETHYLANILINE DERIVATIVES AS ANTICANCER AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-11-25 | — | — | WO | disclosed |