Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 10/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299578 | 0.93 | TOP2A (0.64) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9300784 | 0.92 | TOP2A (0.65) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9300387 | 0.90 | TOP2A (0.72) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9301648 | 0.89 | TOP2A (0.64) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9301141 | 0.88 | TOP2A (0.66) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9300658 | 0.87 | TOP2A (0.64) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL9301553 | 0.86 | TOP2A (0.69) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9299575 | 0.85 | TOP2A (0.62) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9301428 | 0.84 | TOP2A (0.64) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9299690 | 0.84 | TOP2A (0.73) | TOP2ATOP2BKDM1APOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |
| WO-1993023049-A1 | 3-(9-ACRIDINYLAMINO)-5-HYDROXYMETHYLANILINE DERIVATIVES AS ANTICANCER AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-11-25 | — | — | WO | claimed |
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1993023049-A1 | 3-(9-ACRIDINYLAMINO)-5-HYDROXYMETHYLANILINE DERIVATIVES AS ANTICANCER AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-11-25 | — | — | WO | disclosed |