Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963402 | 0.96 | MEN1 (0.37) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL9299840 | 0.91 | CYP2C9 (0.39) | MAPTMEN1KMT2AMAPK1CYP2C9 | |
| SCHEMBL11069186 | 0.88 | MEN1 (0.43) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL11069191 | 0.88 | MEN1 (0.43) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL11066966 | 0.86 | MAPT (0.43) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL11069213 | 0.86 | MAPT (0.43) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL9300714 | 0.85 | OPRL1 (0.31) | OPRL1 | |
| SCHEMBL11073252 | 0.85 | CYP2C9 (0.42) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL11074138 | 0.85 | CYP2C9 (0.42) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL11074551 | 0.85 | CYP2C9 (0.42) | MAPTGAAMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0559860-A1 | HALOVINYL-DERIVATIVES. | HOFFMANN LA ROCHE (CH) | 1993-09-15 | — | — | EP | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |