Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | CRHBP | P24387 | 3/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL79294 | 0.85 | NPC1 (0.45) | SMN1; SMN2CRHBPCRHR2MAPTALDH1A1 | |
| SCHEMBL18410186 | 0.83 | NPC1 (0.40) | ALDH1A1NPC1RAB9ACREBBPICAM1 | |
| SCHEMBL92906 | 0.83 | DRD4 (0.47) | NPC1RAB9ACREBBPTMEM97SIGMAR1 | |
| SCHEMBL8992945 | 0.83 | ICAM1 (0.38) | NPC1RAB9ACREBBPTMEM97SIGMAR1 | |
| SCHEMBL18410184 | 0.81 | ICAM1 (0.40) | NPC1RAB9ACREBBPICAM1SELE | |
| SCHEMBL16077650 | 0.80 | CREBBP (0.46) | SMN1; SMN2ALDH1A1NPC1RAB9ACREBBP | |
| SCHEMBL3078260 | 0.80 | ICAM1 (0.40) | NPC1RAB9ACREBBPICAM1SELE | |
| SCHEMBL30834549 | 0.80 | ICAM1 (0.38) | SMN1; SMN2ALDH1A1NPC1RAB9ACREBBP | |
| SCHEMBL16727109 | 0.80 | ICAM1 (0.38) | SMN1; SMN2ALDH1A1NPC1RAB9ACREBBP | |
| SCHEMBL8321396 | 0.79 | NPC1 (0.50) | MAPTNPC1RAB9AICAM1SELE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129361-B2 | Amine compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20100179216-A1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179216-A1 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | HLA-B, HLA-A, HLA-C | SMN1; SMN2 3560/4885CRHBP 3247/4885CRHR2 1260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.