Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9547301 | 0.88 | TOP2A (0.41) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9300851 | 0.85 | TOP2A (0.49) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9301580 | 0.84 | TOP2A (0.71) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9300857 | 0.80 | TOP2A (0.54) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9300496 | 0.79 | TOP2A (0.52) | TOP2ATOP2BKDM4EMAPTL3MBTL1 | |
| SCHEMBL9300409 | 0.77 | TOP2A (0.45) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9299690 | 0.77 | TOP2A (0.73) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9299915 | 0.77 | TOP2A (0.53) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9299935 | 0.76 | TOP2A (0.68) | TOP2ATOP2BHDAC3HDAC4HDAC1 | |
| SCHEMBL9300420 | 0.76 | TOP2A (0.49) | TOP2ATOP2BHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |