Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25270633 | 0.92 | — | — | |
| SCHEMBL7164814 | 0.92 | CRBN (0.46) | CRBNALDH1A1POLBOR51E2KDM4E | |
| SCHEMBL9082122 | 0.90 | CRBN (0.38) | CRBNALDH1A1POLBPGRAR | |
| SCHEMBL8837747 | 0.90 | CRBN (0.43) | CRBNALDH1A1POLBOR51E2KDM4E | |
| SCHEMBL31599526 | 0.90 | CRBN (0.43) | CRBNALDH1A1OR51E2KDM4EMEN1 | |
| SCHEMBL7171070 | 0.87 | CRBN (0.39) | CRBNALDH1A1POLBOR51E2PGR | |
| SCHEMBL2048532 | 0.84 | NEK2 (0.41) | CRBNALDH1A1OR51E2KDM4EMEN1 | |
| SCHEMBL23752900 | 0.82 | — | — | |
| SCHEMBL25145933 | 0.81 | CRBN (0.40) | CRBNALDH1A1OR51E2KDM4EMEN1 | |
| SCHEMBL4925004 | 0.79 | POLB (0.47) | CRBNALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350743-A | Treatment of osteoporosis | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1994-09-27 | — | — | US | disclosed |
| EP-0498424-A1 | Bisphosphonic acid derivatives and bone resorption inhibitors containing them | Kaken Pharmaceutical Co., Ltd. (JP) | 1992-08-12 | — | — | EP | disclosed |