Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9305089 | 1.00 | MAPT (0.54) | MAPTKMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11339219 | 0.94 | SIRT2 (0.53) | MAPTKMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11339222 | 0.94 | SIRT2 (0.53) | MAPTKMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11325013 | 0.90 | KMT2A (0.50) | MAPTKMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11325016 | 0.90 | KMT2A (0.50) | MAPTKMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7827928 | 0.84 | MEN1 (0.64) | KMT2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7827926 | 0.84 | MEN1 (0.64) | KMT2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20871105 | 0.81 | MAPT (0.62) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL27818030 | 0.81 | MAPT (0.62) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL14337245 | 0.80 | POLB (0.52) | MAPTKMT2APOLBL3MBTL1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843866-A | YAP1 inhibitors targeting YAP1 interaction with OCT4 | H·李·莫菲特癌症中心研究有限公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-106608847-A | Preparation method for imine | 中国科学院大连化学物理研究所 | 2017-05-03 | — | — | CN | disclosed |
| US-5374701-A | Crosslinkable polymers of high strength free of structural defects | HAY ALLAN S (CA) | 1994-12-20 | — | — | US | disclosed |
| US-5233046-A | DIARYLACETYLENES, ENAMINES AND ACETYLENIC POLYMERS AND THEIR PRODUCTION | HAY ALLAN S (CA) | 1993-08-03 | — | — | US | disclosed |
| WO-1993009079-A1 | DIARYLACETYLENES, ENAMINES AND ACETYLENIC POLYMERS AND THEIR PRODUCTION | HAY ALAN S (CA) | 1993-05-13 | — | — | WO | disclosed |
| US-5196606-A | Aromatic tertiary amines, enamines, deoxybenzoins and benzils | HAY ALLAN S (CA) | 1993-03-23 | — | — | US | disclosed |
| US-5117062-A | Aromatic tertiary amines, enamines, deoxybenzoins and benzils | HAY ALLAN S (CA) | 1992-05-26 | — | — | US | disclosed |
| US-5011998-A | Aromatic tertiary amines, enamines, deoxybenzoins and benzils | HAY ALLAN S (CA) | 1991-04-30 | — | — | US | disclosed |