Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307376 | 1.00 | HSD17B10 (0.55) | HSD17B10NPSR1POLBEPHX2MEN1 | |
| Iodide SCHEMBL9305579 | 0.94 | HSD17B10 (0.56) | HSD17B10NPSR1POLBEPHX2MEN1 | |
| Iodide SCHEMBL9305151 | 0.94 | HSD17B10 (0.56) | HSD17B10NPSR1POLBEPHX2MEN1 | |
| Iodide SCHEMBL9309198 | 0.89 | S1PR2 (0.45) | HSD17B10NPSR1MEN1KMT2A | |
| Iodide SCHEMBL9307084 | 0.89 | S1PR2 (0.45) | HSD17B10NPSR1MEN1KMT2A | |
| Iodide SCHEMBL9307470 | 0.88 | NPSR1 (0.42) | HSD17B10NPSR1 | |
| Iodide SCHEMBL9309074 | 0.88 | NPSR1 (0.42) | HSD17B10NPSR1 | |
| Iodide SCHEMBL9306603 | 0.85 | SMPD1 (0.54) | — | |
| Iodide SCHEMBL9307001 | 0.85 | SMPD1 (0.54) | — | |
| Iodide SCHEMBL9307938 | 0.85 | SMPD1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |