Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307165 | 1.00 | SMPD1 (0.39) | SMPD1PPARGPPARATHRATHRB | |
| Iodide SCHEMBL9307872 | 1.00 | SMPD1 (0.39) | SMPD1PPARGPPARATHRATHRB | |
| Iodide SCHEMBL9307182 | 0.94 | PPARG (0.41) | SMPD1PPARGPPARATHRATHRB | |
| Iodide SCHEMBL9305373 | 0.89 | SMPD1 (0.40) | SMPD1PPARGPPARATHRATHRB | |
| Iodide SCHEMBL9307513 | 0.82 | PPARG (0.40) | PPARGPPARA | |
| Iodide SCHEMBL9306940 | 0.77 | C5 (0.49) | SMPD1 | |
| Iodide SCHEMBL9306385 | 0.77 | C5 (0.43) | SMPD1THRATHRB | |
| Iodide SCHEMBL9307270 | 0.77 | C5 (0.43) | SMPD1THRATHRB | |
| Iodide SCHEMBL9307269 | 0.77 | C5 (0.43) | SMPD1THRATHRB | |
| Iodide SCHEMBL9308062 | 0.76 | C5 (0.42) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |