Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.70 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | THRA | P10827 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204104 | 1.00 | SMPD1 (0.70) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL1331352 | 1.00 | SMPD1 (0.70) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL9906433 | 1.00 | SMPD1 (0.70) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL15779400 | 1.00 | SMPD1 (0.70) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL11337002 | 1.00 | SMPD1 (0.70) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL8465014 | 0.98 | SMPD1 (0.68) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL5202638 | 0.94 | KMT2A (0.62) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL11422303 | 0.92 | PRSS1 (0.60) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL1330972 | 0.89 | SMPD1 (0.57) | SMPD1PLA2G4BTHRBTHRAKMT2A | |
| SCHEMBL1329130 | 0.89 | SMPD1 (0.57) | SMPD1PLA2G4BTHRBTHRAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |