Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.77 |
| ▸ | PLK1 | P53350 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | STAT3 | P40763 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.67 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.67 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.67 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.67 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.67 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.67 |
| ▸ | FAAH | O00519 | 6/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257510 | 0.96 | NR1H4 (0.76) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL9453351 | 0.94 | NR1H4 (0.73) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL22192246 | 0.88 | SMN1; SMN2 (0.81) | NR1H4LMNASTAT3SMN1; SMN2TP53 | |
| SCHEMBL6725370 | 0.88 | NR1H4 (0.61) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL6725374 | 0.88 | NR1H4 (0.61) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL2832501 | 0.88 | SMN1; SMN2 (0.67) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL8390939 | 0.88 | SMN1; SMN2 (0.67) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL8756930 | 0.88 | SMN1; SMN2 (0.67) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL8363016 | 0.88 | SMN1; SMN2 (0.67) | NR1H4PLK1LMNASTAT3SMN1; SMN2 | |
| SCHEMBL8390958 | 0.88 | SMN1; SMN2 (0.67) | NR1H4PLK1LMNASTAT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |