Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.44 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307807 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9307322 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9306260 | 0.94 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9306759 | 0.92 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9307439 | 0.92 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9307193 | 0.84 | USP2 (0.47) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9306343 | 0.84 | USP2 (0.47) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9305740 | 0.84 | USP2 (0.47) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9308938 | 0.84 | USP2 (0.47) | SMN1; SMN2HPGDCYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9309398 | 0.81 | SMPD1 (0.42) | USP2MAPK1SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |