Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 19/20 | 0.98 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quiflapon SCHEMBL29372303 | 0.99 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL29370879 | 0.99 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL30505315 | 0.99 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL502947 | 0.99 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL9306842 | 0.98 | ALOX5AP (0.98) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2109210 | 0.94 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2108829 | 0.93 | ALOX5AP (0.89) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL27899653 | 0.93 | ALOX5AP (0.88) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9185735 | 0.92 | ALOX5AP (0.86) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL1229503 | 0.92 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321033-A | Anti-asthmatic, anti-allergenic or cryptoprotective | MERCK FROSST CANADA, INC. | 1994-06-14 | — | — | US | disclosed |
| US-5254567-A | Antihistamines, antiinflammatory agent, antiallergens, cytoprotective agent | MERCK FROSST CANADA, INC. (CA) | 1993-10-19 | — | — | US | disclosed |
| WO-1993010115-A1 | AMORPHOUS (QUINOLIN-2-YLMETHOXY) INDOLES AS LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1993-05-27 | — | — | WO | disclosed |
| EP-0542355-A1 | Amorphous (Quinolin-2-ylmethoxy)indoles as leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1993-05-19 | — | — | EP | disclosed |