Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.52 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9308954 | 1.00 | S1PR2 (0.52) | S1PR2S1PR1S1PR3LPAR2EPHX2 | |
| Iodide SCHEMBL9306451 | 0.91 | S1PR2 (0.52) | S1PR2S1PR1S1PR3LPAR2EPHX2 | |
| Iodide SCHEMBL9307877 | 0.89 | SMPD1 (0.56) | ROCK2SMPD1CNR2 | |
| Iodide SCHEMBL9309073 | 0.89 | SMPD1 (0.56) | ROCK2SMPD1CNR2 | |
| Iodide SCHEMBL9307378 | 0.89 | S1PR2 (0.52) | S1PR2S1PR1S1PR3LPAR2 | |
| Iodide SCHEMBL9307604 | 0.88 | S1PR2 (0.55) | S1PR2S1PR1S1PR3LPAR2EPHX2 | |
| Iodide SCHEMBL9308248 | 0.85 | S1PR2 (0.56) | S1PR2S1PR1S1PR3LPAR2EPHX2 | |
| Iodide SCHEMBL9308584 | 0.85 | S1PR2 (0.56) | S1PR2S1PR1S1PR3LPAR2EPHX2 | |
| Iodide SCHEMBL9305372 | 0.84 | S1PR2 (0.55) | S1PR2S1PR1S1PR3LPAR2EPHX2 | |
| Iodide SCHEMBL9306429 | 0.84 | S1PR2 (0.55) | S1PR2S1PR1S1PR3LPAR2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |