Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307350 | 1.00 | HSD17B10 (0.58) | HSD17B10EPHX2NPSR1S1PR2S1PR1 | |
| Iodide SCHEMBL9307295 | 0.95 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1S1PR2S1PR1 | |
| Iodide SCHEMBL9308081 | 0.95 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1S1PR2S1PR1 | |
| Iodide SCHEMBL9307010 | 0.92 | HSD17B10 (0.58) | HSD17B10EPHX2NPSR1S1PR2S1PR1 | |
| Iodide SCHEMBL9307860 | 0.92 | HSD17B10 (0.58) | HSD17B10EPHX2NPSR1S1PR2S1PR1 | |
| Iodide SCHEMBL9308500 | 0.89 | S1PR2 (0.48) | HSD17B10EPHX2NPSR1S1PR2S1PR1 | |
| Iodide SCHEMBL9308103 | 0.89 | S1PR2 (0.48) | HSD17B10EPHX2NPSR1S1PR2S1PR1 | |
| Iodide SCHEMBL9309538 | 0.88 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1 | |
| Iodide SCHEMBL9307156 | 0.88 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1 | |
| Iodide SCHEMBL9308855 | 0.87 | HSD17B10 (0.44) | HSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |