SCHEMBL9309681

SCHEMBL9309681

CCCCCC(CCn1sc(Cl)cc1=O)=NOC

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT2B Q92831 10/20 0.60
CA2 P00918 1/20 0.37
ALDH1A1 P00352 2/20 0.31
TP53 P04637 1/20 0.31
HSP90AA1 P07900 1/20 0.31
CYP3A4 P08684 1/20 0.31
G6PD P11413 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31
HIF1A Q16665 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA9 Q16790 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
PAK1 Q13153 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9308434 0.79 KAT2B (0.70) KAT2BCA2ALDH1A1TP53HSP90AA1
SCHEMBL9309685 0.76 KAT2B (0.47) KAT2BCA2ALDH1A1CYP1A2CYP2C19
SCHEMBL9565234 0.75 KAT2B (0.97) KAT2BALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL1851730 0.75 KAT2B (0.97) KAT2BALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL8062252 0.75 KAT2B (0.97) KAT2BALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL11193788 0.75 KAT2B (0.97) KAT2BALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL929340 0.75 KAT2B (0.90) KAT2BALDH1A1TP53HSP90AA1CYP3A4
Hydrochloric Acid SCHEMBL11713957 0.73 KAT2B (0.90) KAT2BALDH1A1TP53HSP90AA1CYP3A4
Hydrochloric Acid SCHEMBL11713961 0.73 KAT2B (0.90) KAT2BALDH1A1TP53HSP90AA1CYP3A4
Hydrochloric Acid SCHEMBL10496287 0.73 KAT2B (0.90) KAT2BALDH1A1TP53HSP90AA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630891-A1 3-Isothiazolones derivatives and their use as antimicrobial agents ROHM AND HAAS COMPANY (US) 1994-12-28 EP disclosed
US-5321141-A Reacting an isothiazole with an a,b-unsaturated ketone or aldehyde ROHM AND HAAS COMPANY (US) 1994-06-14 US disclosed
US-5288693-A Microbiocides ROHM AND HAAS COMPANY (US) 1994-02-22 US disclosed