⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27623038 | 0.97 | — | — | |
| SCHEMBL11254821 | 0.76 | SLC22A6 (0.36) | — | |
| SCHEMBL3421787 | 0.75 | SLC22A6 (0.43) | — | |
| SCHEMBL28070675 | 0.75 | SLC22A6 (0.43) | — | |
| SCHEMBL10708540 | 0.75 | SLC22A6 (0.43) | — | |
| SCHEMBL5374 | 0.75 | — | — | |
| SCHEMBL28012302 | 0.75 | — | — | |
| Ammonia Solution, Strong SCHEMBL18008083 | 0.73 | — | — | |
| SCHEMBL125162 | 0.73 | — | — | |
| Fluoride SCHEMBL14840242 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448930-A1 | COVALENT INHIBITION OF BACTERIAL QUORUM SENSING | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2012-05-09 | — | — | EP | claimed |
| WO-2011001419-A1 | COVALENT INHIBITION OF BACTERIAL QUORUM SENSING | NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV (IL) | 2011-01-06 | — | — | WO | claimed |
| CN-108976153-A | Antibacterial hydrophilic compounds and application | 深圳大学 | 2018-12-11 | — | — | CN | disclosed |
| EP-2448930-B1 | N-((S)-2-Oxo-tetrahydro-furan-3-yl)-amide derivatives as inhibitors of the bacterial quorum sensing for treating plant or animal diseases and for preventing the formation of biofilms on medical devices | THE NAT INST FOR BIOTECHNOLOGY IN THE NEGEV LTD (IL) | 2017-02-15 | — | — | EP | disclosed |
| CN-105531258-A | Reactive antibacterial compound and preparation method thereof | UNIV SHENZHEN | 2016-04-27 | — | — | CN | disclosed |
| US-9242951-B2 | Covalent inhibition of bacterial quorum sensing | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2016-01-26 | — | — | US | disclosed |
| US-20140073690-A1 | COVALENT INHIBITION OF BACTERIAL QUORUM SENSING | NAT INST FOR BIOTECHNOLOGY IN THE NEGEV LTD (IL) | 2014-03-13 | — | — | US | disclosed |
| US-8501969-B2 | Covalent inhibition of bacterial quorum sensing | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2013-08-06 | — | — | US | disclosed |
| US-20120135925-A1 | Covalent Inhibition of Bacterial Quorum Sensing | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2012-05-31 | — | — | US | disclosed |
| EP-2448930-A1 | COVALENT INHIBITION OF BACTERIAL QUORUM SENSING | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001419-A1 | COVALENT INHIBITION OF BACTERIAL QUORUM SENSING | NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV (IL) | 2011-01-06 | — | — | WO | disclosed |
| US-4141734-A | SUBSTITUTED ORGANIC DI- OR TRISULFIDE ANTIDEPOSIT AGENTS | CIBA-GEIBY AG (CH) | 1979-02-27 | — | — | US | disclosed |