Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL291412 | 0.86 | TSHR (0.59) | TSHRKCNH2KCNJ1MAPTALDH1A1 | |
| SCHEMBL291413 | 0.85 | TSHR (0.58) | TSHRKCNH2KCNJ1MAPTRAB9A | |
| SCHEMBL11027107 | 0.84 | TSHR (0.50) | TSHRKCNH2MAOBMAPK1KCNJ1 | |
| SCHEMBL27483143 | 0.84 | TSHR (0.53) | TSHRKCNH2KCNJ1ALDH1A1CHRM5 | |
| SCHEMBL1276349 | 0.84 | TSHR (0.53) | TSHRKCNH2KCNJ1MAPTRAB9A | |
| SCHEMBL5182834 | 0.83 | TSHR (0.56) | TSHRKCNH2KCNJ1MAPTALDH1A1 | |
| SCHEMBL9676461 | 0.83 | TSHR (0.56) | TSHRKCNH2KCNJ1MAPTALDH1A1 | |
| SCHEMBL1282588 | 0.83 | TSHR (0.56) | TSHRKCNH2MAPK1KCNJ1MAPT | |
| SCHEMBL4567587 | 0.83 | MAOB (0.59) | MAOBMAPTRAB9AALDH1A1IDO1 | |
| SCHEMBL26448818 | 0.83 | EPHX1 (0.52) | TSHRKCNH2KCNJ1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024156288-A1 | DNMT1 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | SHANGHAI KYGENT PHARMACEUTICAL CO., LTD (CN) | 2024-08-02 | — | — | WO | disclosed |
| WO-2017008708-A1 | METHOD FOR PREPARING INDAZOLE COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2017-01-19 | — | — | WO | disclosed |
| US-9249308-B2 | Compound having bisazo dye skeleton, pigment composition containing the same, pigment dispersion, ink, and color filter resist composition | CANON KABUSHIKI KAISHA (JP) | 2016-02-02 | — | — | US | disclosed |
| US-20140326931-A1 | NOVEL COMPOUND HAVING BISAZO DYE SKELETON, PIGMENT COMPOSITION CONTAINING THE SAME, PIGMENT DISPERSION, INK, AND COLOR FILTER RESIST COMPOSITION | CANON KABUSHIKI KAISHA (JP) | 2014-11-06 | — | — | US | disclosed |
| CN-103534257-A | Pyrrolo [2, 3 -d] pyrimidine derivatives as inhibitors of tropomyosin- related kinases | PFIZER | 2014-01-22 | — | — | CN | disclosed |
| CN-1245394-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2006-03-15 | — | — | CN | disclosed |
| CN-1185220-C | Para-substituted phenylamide glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-01-19 | — | — | CN | disclosed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1427830-A | Para-substituted phenylamide glucokinase activators | HOFFMANN LA ROCHE (CH) | 2003-07-02 | — | — | CN | disclosed |
| CN-1427829-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2003-07-02 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |
| EP-0592552-A1 | CHIRAL PHOSPHOLANES VIA CHIRAL 1,4-DIOL CYCLIC SULFATES. | DU PONT (US) | 1994-04-20 | — | — | EP | disclosed |