Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL9316307

Clc1cccc(-c2ccccc2)c1.Clc1cccc(-c2ccccc2)c1.S

nearest known ligand 0.59

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.59
ALOX5 P09917 1/20 0.56
TSHR P16473 2/20 0.55
NPC1 O15118 1/20 0.55
TP53 P04637 1/20 0.55
NFKB1 P19838 1/20 0.55
RAB9A P51151 1/20 0.55
NFKB2 Q00653 1/20 0.55
RELA Q04206 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
CYP1A2 P05177 1/20 0.55
MAOB P27338 2/20 0.53
ESR2 Q92731 2/20 0.50
SCN2A Q99250 1/20 0.48
IDO1 P14902 1/20 0.48
MAOA P21397 1/20 0.48
ALDH1A1 P00352 1/20 0.47
ADORA2A P29274 1/20 0.47
ADORA1 P30542 1/20 0.47
PGR P06401 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL27896829 1.00 TAAR1 (0.59) TAAR1ALOX5TSHRNPC1TP53
SCHEMBL29788033 0.97 TAAR1 (0.61) TAAR1ALOX5TSHRNPC1TP53
SCHEMBL170231 0.97 TAAR1 (0.61) TAAR1ALOX5TSHRNPC1TP53
SCHEMBL29380954 0.95 TAAR1 (0.59) TAAR1ALOX5TSHRNPC1TP53
Hydrochloric Acid SCHEMBL28870177 0.95 TAAR1 (0.59) TAAR1ALOX5TSHRNPC1TP53
SCHEMBL16394095 0.95 TAAR1 (0.65) TAAR1ALOX5TSHRNPC1TP53
SCHEMBL5539603 0.95 TAAR1 (0.59) TAAR1ALOX5TSHRNPC1TP53
Hydrochloric Acid SCHEMBL28808204 0.95 TAAR1 (0.59) TAAR1ALOX5TSHRNPC1TP53
SCHEMBL19501160 0.95 TAAR1 (0.59) TAAR1ALOX5TSHRNPC1TP53
Water SCHEMBL11024520 0.95 TAAR1 (0.59) TAAR1ALOX5TSHRNPC1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5288848-A Reacting mono- and dihalogenated aromatics with alkali sulfide ; low corrosion during processing BAYER AKTIENGESELLSCHAFT (DE) 1994-02-22 US disclosed
US-4760127-A Reacting dihalogen aromatics and alkali metal sulfide in presence of a monohalogen compound and a monomercapto compound BAYER AG (DE) 1988-07-26 US disclosed