Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 8/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280195 | 0.87 | SLC7A5 (0.71) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL29585153 | 0.87 | SLC7A5 (0.71) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL1249808 | 0.87 | SLC7A5 (0.71) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3279504 | 0.83 | SLC7A5 (0.60) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3277300 | 0.83 | SLC7A5 (0.60) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL9316537 | 0.83 | SLC7A5 (0.60) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3277307 | 0.83 | SLC7A5 (0.60) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL26980982 | 0.81 | SLC7A5 (0.58) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL30004590 | 0.81 | HIF1A (0.58) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL26980960 | 0.81 | SLC7A5 (0.58) | SLC7A5PTGS1KDM4EUSP2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |