Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 11/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631360 | 0.94 | P4HTM (0.58) | P4HTMSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL3621496 | 0.84 | P4HTM (0.59) | P4HTMMAPK1ALDH1A1 | |
| SCHEMBL25733687 | 0.78 | P4HTM (0.58) | P4HTMHDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL3621493 | 0.76 | P4HTM (0.63) | P4HTMSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL9140990 | 0.75 | P4HTM (0.66) | P4HTM | |
| SCHEMBL19151154 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1MAPTHSD17B10 | |
| SCHEMBL30112058 | 0.74 | P4HTM (0.60) | P4HTMMAPTMAPK1ALDH1A1 | |
| SCHEMBL18405340 | 0.74 | P4HTM (0.60) | P4HTMMAPTMAPK1ALDH1A1 | |
| SCHEMBL28500470 | 0.74 | P4HTM (0.61) | P4HTMHDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL30826511 | 0.74 | P4HTM (0.61) | P4HTMHDAC3HDAC4HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |