⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butanedione SCHEMBL9878247 | 0.83 | TSHR (0.58) | — | |
| Acetamide SCHEMBL29032534 | 0.78 | — | — | |
| Thioacetamide SCHEMBL28155309 | 0.78 | — | — | |
| Butanedione SCHEMBL10788198 | 0.77 | TSHR (0.50) | — | |
| Acetic Acid SCHEMBL2186621 | 0.75 | FFAR3 (0.58) | — | |
| Acetone SCHEMBL28842497 | 0.75 | — | — | |
| Acetic Acid SCHEMBL7894019 | 0.75 | — | — | |
| Acetic Acid SCHEMBL3803565 | 0.75 | FFAR3 (0.58) | — | |
| Acetic Acid SCHEMBL27528692 | 0.75 | — | — | |
| SCHEMBL13484716 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110615751-B | Preparation method of 2-oxo-thiopropionamide | 上海医药工业研究院 | 2021-08-17 | — | — | CN | claimed |
| CN-110615751-A | Preparation method of 2-oxo-thiopropionamide | 上海医药工业研究院 | 2019-12-27 | — | — | CN | claimed |
| EP-3064494-A1 | A PROCESS FOR THE PREPARATION OF A CAMSYLATE SALT ((1S)-(+)-10 CAMPHORSULFONIC ACID) OF (1R,1'R,4R)- 4-METHOXY-5\"-METHYL-6'-[5-(PROP-1-YN-1-YL)PYRIDIN- 3-YL]-3'H-DISPIRO[CYCLOHEXANE-1,2'-INDEN-1'2'-IMIDAZOLE]-4\"-AMINE | AstraZeneca AB (SE) | 2016-09-07 | — | — | EP | claimed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| CN-110938083-B | Compounds as BACE1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-110615751-B | Preparation method of 2-oxo-thiopropionamide | 上海医药工业研究院 | 2021-08-17 | — | — | CN | disclosed |
| CN-110615751-B | Preparation method of 2-oxo-thiopropionamide | 上海医药工业研究院 | 2021-08-17 | — | — | CN | disclosed |
| CN-110615751-B | Preparation method of 2-oxo-thiopropionamide | 上海医药工业研究院 | 2021-08-17 | — | — | CN | disclosed |
| CN-110938083-A | Compounds as BACE1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2020-03-31 | — | — | CN | disclosed |
| US-10548882-B2 | Camsylate salt | ASTRAZENECA AB (SE) | 2020-02-04 | — | — | US | disclosed |
| EP-3176172-B1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2020-01-29 | — | — | EP | disclosed |
| EP-3176172-B1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2020-01-29 | — | — | EP | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| US-20100152162-A1 | THERAPEUTIC AND/OR PREVENTIVE AGENTS FOR A SLEEP DISORDER | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-17 | — | — | US | disclosed |
| US-7612075-B2 | Substituted oxoazaheterocyclyl compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20090011024-A1 | Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers | PFIZER INC. | 2009-01-08 | — | — | US | disclosed |
| US-20080292707-A1 | Pharmaceutical Compositions of Adsorbates of Amorphous Drug | PFIZER INC | 2008-11-27 | — | — | US | disclosed |
| US-20070148236-A1 | Pharmaceutical Compositions of Adsorbates of Amorphous Drug | PFIZER PRODUCTS INC. | 2007-06-28 | — | — | US | disclosed |