Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | FASN | P49327 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 4/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 6/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | DRD1 | P21728 | 4/20 | 0.39 |
| ▸ | DRD5 | P21918 | 4/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9809572 | 1.00 | CYP3A4 (0.48) | CYP3A4CYP2C9FASNAPPAKR1C3 | |
| SCHEMBL12377041 | 0.88 | FASN (0.49) | CYP3A4CYP2C9FASNAPPCYP2D6 | |
| SCHEMBL6455881 | 0.87 | APP (0.41) | CYP3A4CYP2C9FASNAPPAKR1C3 | |
| SCHEMBL6455885 | 0.87 | APP (0.41) | CYP3A4CYP2C9FASNAPPAKR1C3 | |
| SCHEMBL16326213 | 0.87 | CYP2C9 (0.41) | CYP3A4CYP2C9FASNAPPAKR1C3 | |
| SCHEMBL16317705 | 0.85 | FASN (0.47) | CYP3A4CYP2C9FASNAPPCYP2D6 | |
| SCHEMBL9319293 | 0.85 | CYP3A4 (0.46) | CYP3A4CYP2C9FASNAPPAKR1C3 | |
| SCHEMBL9809581 | 0.85 | CYP3A4 (0.46) | CYP3A4CYP2C9FASNAPPAKR1C3 | |
| SCHEMBL8997327 | 0.84 | CYP2C9 (0.45) | CYP3A4CYP2C9FASNAPPAKR1C3 | |
| SCHEMBL8997321 | 0.84 | CYP2C9 (0.45) | CYP3A4CYP2C9FASNAPPAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292454-A | Trifluorotoluene compounds, and a liquid crystalline medium | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-03-08 | — | — | US | disclosed |