Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7390950 | 1.00 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL9319919 | 0.90 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL7499687 | 0.87 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL11840218 | 0.87 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL11840227 | 0.87 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4CLMNA | |
| Tolafentrine SCHEMBL29992625 | 0.84 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Tolafentrine SCHEMBL8326829 | 0.84 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL5058869 | 0.84 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Tolafentrine SCHEMBL4450984 | 0.84 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Tolafentrine SCHEMBL159331 | 0.84 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346904-A | BRONCHODILATOR AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-09-13 | — | — | US | disclosed |