Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 1.00 |
| ▸ | LCK | P06239 | 4/20 | 0.61 |
| ▸ | XDH | P47989 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | TTR | P02766 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320169 | 1.00 | EGFR (1.00) | EGFRLCKXDHKDM4EALDH1A1 | |
| SCHEMBL17308143 | 0.82 | EGFR (0.69) | EGFRLCKXDHKDM4EALDH1A1 | |
| SCHEMBL1824175 | 0.78 | LCK (1.00) | EGFRLCKXDHKDM4EALDH1A1 | |
| SCHEMBL1824176 | 0.78 | LCK (1.00) | EGFRLCKXDHKDM4EALDH1A1 | |
| SCHEMBL31706727 | 0.78 | LCK (1.00) | EGFRLCKXDHKDM4EALDH1A1 | |
| SCHEMBL30631591 | 0.78 | LCK (1.00) | EGFRLCKXDHKDM4EALDH1A1 | |
| SCHEMBL28350331 | 0.77 | EGFR (0.62) | EGFRKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL9321542 | 0.77 | EGFR (0.62) | EGFRKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL9321547 | 0.77 | EGFR (0.62) | EGFRKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL30353498 | 0.76 | PTGS1 (0.61) | EGFRLCKXDHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440887-B1 | Improvement in the total synthesis of Erbstatin analogs | ERBA CARLO SPA (IT) | 1994-01-26 | — | — | EP | disclosed |
| US-5130472-A | TOTAL SYNTHESIS OF ERBSTATIN ANALOGS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-07-14 | — | — | US | disclosed |
| EP-0440887-A1 | Improvement in the total synthesis of Erbstatin analogs | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-14 | — | — | EP | disclosed |
| US-4925877-A | ANTITUMOR AGENTS, BACTERICIDES, ENZYME INHIBITOR | ZAIDANHOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1990-05-15 | — | — | US | disclosed |
| EP-0238868-A2 | New physiologically active substance erbstatin analogous compounds | Zaidanhojin Biseibutsu Kagaku Kenkyukai (JP) | 1987-09-30 | — | — | EP | disclosed |