Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.85 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.75 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.75 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029902 | 0.92 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1030422 | 0.88 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL931988 | 0.88 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1028190 | 0.86 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1028453 | 0.85 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CA | |
| SCHEMBL1028435 | 0.85 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1026564 | 0.85 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1030291 | 0.85 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1027151 | 0.84 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CA | |
| SCHEMBL12943531 | 0.84 | AKT1 (0.79) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448932-B1 | NOVEL 6-MORPHOLIN-4-YL-PYRIMIDIN-4-(3H)-ONE DERIVATIVES, AND THE PHARMACEUTICAL PREPARATION THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI SA (FR) | 2014-03-05 | — | — | EP | disclosed |
| EP-2448932-B1 | NOVEL 6-MORPHOLIN-4-YL-PYRIMIDIN-4-(3H)-ONE DERIVATIVES, AND THE PHARMACEUTICAL PREPARATION THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI SA (FR) | 2014-03-05 | — | — | EP | disclosed |
| US-8507483-B2 | 1H-pyrimidin-2-one derivatives, preparation thereof and pharmaceutical use thereof as inhibitors of AKT (PKB) phosphorylation | SANOFI (FR) | 2013-08-13 | — | — | US | disclosed |
| US-8507483-B2 | 1H-pyrimidin-2-one derivatives, preparation thereof and pharmaceutical use thereof as inhibitors of AKT (PKB) phosphorylation | SANOFI (FR) | 2013-08-13 | — | — | US | disclosed |
| EP-2448932-A1 | NOVEL 6-MORPHOLIN-4-YL-PYRIMIDIN-4-(3H)-ONE DERIVATIVES, AND THE PHARMACEUTICAL PREPARATION THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001115-A1 | NOVEL 6-MORPHOLIN-4-YL-PYRIMIDIN-4-(3H)-ONE DERIVATIVES, AND THE PHARMACEUTICAL PREPARATION THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI-AVENTIS (FR) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011001115-A1 | NOVEL 6-MORPHOLIN-4-YL-PYRIMIDIN-4-(3H)-ONE DERIVATIVES, AND THE PHARMACEUTICAL PREPARATION THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI-AVENTIS (FR) | 2011-01-06 | — | — | WO | disclosed |