Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 7/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.35 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665214 | 0.94 | HMGCR (0.42) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL9665217 | 0.94 | HMGCR (0.42) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL9318925 | 0.90 | HMGCR (0.49) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL9662629 | 0.85 | HMGCR (0.53) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL9662639 | 0.85 | HMGCR (0.53) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL6956310 | 0.83 | HMGCR (0.60) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL10650833 | 0.83 | HMGCR (0.46) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL9318838 | 0.81 | HMGCR (0.48) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL9321315 | 0.80 | AR (0.43) | AR | |
| SCHEMBL9664046 | 0.80 | AR (0.43) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373423-B1 | Substituted 2-pyridones and pyride-2-thiones, process for their preparation and their use in medicine | BAYER AG (DE) | 1994-01-12 | — | — | EP | disclosed |
| EP-0373423-A1 | Substituted 2-pyridones and pyride-2-thiones, process for their preparation and their use in medicine | BAYER AG (DE) | 1990-06-20 | — | — | EP | disclosed |