Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL7268462 | 1.00 | TSHR (0.60) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL28810745 | 0.95 | TSHR (0.55) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL11439058 | 0.95 | TSHR (0.67) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL137177 | 0.95 | — | — | |
| Benzene SCHEMBL27992094 | 0.90 | TSHR (0.60) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL8985498 | 0.90 | TSHR (0.60) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL28183512 | 0.90 | TSHR (0.60) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL10997806 | 0.90 | TSHR (0.60) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL27579085 | 0.90 | TSHR (0.60) | TSHRALDH1A1TP53FFAR3LMNA | |
| Benzene SCHEMBL28158931 | 0.90 | TSHR (0.60) | TSHRALDH1A1TP53FFAR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 362 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110433105-A | A kind of eye shadow and its manufacturing method | ZHONGSHAN MEIYUAN COSMETICS CO LTD | 2019-11-12 | — | — | CN | claimed |
| CN-110420127-A | A kind of essence and preparation method thereof with pearlescent appearance | SHAANXI HUIKANG BIOTECHNOLOGY CO LTD | 2019-11-08 | — | — | CN | claimed |
| CN-110354040-A | A kind of skin care item and preparation method thereof of bright color maintenance skin | 汇云聚美(广州)科技有限公司 | 2019-10-22 | — | — | CN | claimed |
| CN-110279598-A | A kind of whitening and spot eliminating cream preparation method | 许富明 | 2019-09-27 | — | — | CN | claimed |
| CN-110237008-A | A kind of grape pip elastic force mildy wash and preparation method thereof | 广州药妆日用化工有限公司 | 2019-09-17 | — | — | CN | claimed |
| CN-110227043-A | Composition, preparation method and cosmetics with anti-corrosion moisture-keeping efficacy | 韩后化妆品股份有限公司 | 2019-09-13 | — | — | CN | claimed |
| CN-110179723-A | A kind of multiple isolation times shield sunscreen spray | 许富明 | 2019-08-30 | — | — | CN | claimed |
| CN-110151589-A | Skin-activating whitening facial mask and preparation method thereof | 广州维真渼生物科技有限公司 | 2019-08-23 | — | — | CN | claimed |
| CN-110151610-A | A kind of seaweed moisturizing essence and preparation method thereof | 青岛明月海藻生物健康科技集团有限公司 | 2019-08-23 | — | — | CN | claimed |
| CN-106580798-B | Full-effect eye cream and preparation method thereof | 广东科盈科技有限公司 | 2019-08-20 | — | — | CN | claimed |
| CN-106074291-A | A kind of Artemisia argyi Levl. et Van. var. argyi cv. Qiai bacteriostatic lotion | 湖北艾源蕲艾科技有限公司 | 2016-11-09 | — | — | CN | claimed |
| CN-106074315-A | A kind of facial mask liquid with multiple skin-care effect and preparation method thereof | 广东芭薇生物科技股份有限公司 | 2016-11-09 | — | — | CN | claimed |
| CN-105997754-A | Camellia extraction liquid, and preparation method and application thereof | 上海得高实业有限公司 | 2016-10-12 | — | — | CN | claimed |
| CN-105994355-A | Clinical surgical instrument sanitizer | 王兰英 | 2016-10-12 | — | — | CN | claimed |
| CN-105997828-A | Smearing type moistening and brightening essence liquid | 广州艾蓓生物科技有限公司 | 2016-10-12 | — | — | CN | claimed |
| CN-105943491-A | Moistening and moisturizing essence and preparation method thereof | 广州市巧美化妆品有限公司 | 2016-09-21 | — | — | CN | claimed |
| CN-105943433-A | Skin-whitening composition as well as preparation method and applications thereof | 杭州西顿生物科技有限公司 | 2016-09-21 | — | — | CN | claimed |
| CN-205517681-U | Phenoxyethanol reaction unit | 天津宏道润达科技有限公司 | 2016-08-31 | — | — | CN | claimed |
| CN-105878058-A | EE cream | 成都荣乐化妆品有限公司 | 2016-08-24 | — | — | CN | claimed |
| CN-105726367-A | Foundation make-up containing natural mineral color clay and preparing method thereof | 广州智媛生物科技有限公司 | 2016-07-06 | — | — | CN | claimed |