Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9322386 | 0.89 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9321578 | 0.88 | AKR1B1 (0.80) | AKR1B1 | |
| SCHEMBL9323603 | 0.86 | AKR1B1 (0.64) | AKR1B1 | |
| SCHEMBL9322507 | 0.78 | AKR1B1 (0.80) | AKR1B1 | |
| SCHEMBL1590287 | 0.78 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9321335 | 0.77 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9324060 | 0.74 | AKR1B1 (0.80) | AKR1B1 | |
| SCHEMBL9320882 | 0.73 | AKR1B1 (0.60) | AKR1B1 | |
| SCHEMBL9872753 | 0.73 | AKR1B1 (0.87) | AKR1B1 | |
| SCHEMBL9321288 | 0.73 | AKR1B1 (0.77) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330997-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5236945-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0325375-B1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1989006651-A1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0325375-A1 | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1989-07-26 | — | — | EP | disclosed |