Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 15/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.38 |
| ▸ | FLT4 | P35916 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL468096 | 0.91 | PTPRB (0.53) | PTPRBFLT1FLT4KDRVCP | |
| SCHEMBL500277 | 0.88 | PTPRB (0.59) | PTPRB | |
| SCHEMBL500276 | 0.88 | PTPRB (0.59) | PTPRB | |
| SCHEMBL468151 | 0.83 | PTPRB (0.43) | PTPRBFLT1FLT4KDRVCP | |
| SCHEMBL12943898 | 0.80 | PTPRB (0.53) | PTPRB | |
| SCHEMBL468205 | 0.80 | PTPRB (0.42) | PTPRB | |
| SCHEMBL500134 | 0.79 | PTPRB (0.67) | PTPRB | |
| SCHEMBL500135 | 0.79 | PTPRB (0.67) | PTPRB | |
| SCHEMBL467271 | 0.79 | PTPRB (0.47) | PTPRB | |
| SCHEMBL683498 | 0.77 | PTPRB (0.51) | PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451279-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS | Akebia Therapeutics Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005330-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS | AKEBIA THERAPEUTICS INC. (US) | 2011-01-13 | — | — | WO | disclosed |