Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.60 |
| ▸ | APP | P05067 | 2/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18926487 | 0.86 | BACE1 (0.65) | BACE1APP | |
| SCHEMBL931202 | 0.85 | BACE1 (0.59) | BACE1APPBACE2 | |
| SCHEMBL21654466 | 0.79 | BACE1 (0.66) | BACE1APPBACE2 | |
| SCHEMBL1173053 | 0.77 | BACE1 (0.79) | BACE1APPBACE2 | |
| SCHEMBL18927139 | 0.77 | BACE1 (0.67) | BACE1APPBACE2 | |
| SCHEMBL20628895 | 0.76 | BACE1 (0.75) | BACE1BACE2 | |
| SCHEMBL18926394 | 0.75 | BACE1 (0.66) | BACE1APPBACE2 | |
| SCHEMBL2582451 | 0.75 | BACE1 (1.00) | BACE1BACE2 | |
| SCHEMBL14551021 | 0.75 | BACE1 (1.00) | BACE1BACE2 | |
| SCHEMBL7707681 | 0.75 | BACE1 (1.00) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |