Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 14/20 | 0.73 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.60 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.60 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.60 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325087 | 1.00 | TACR1 (0.73) | TACR1CACNA1FCHRM5CACNA1DCACNA1S | |
| SCHEMBL9325094 | 1.00 | TACR1 (0.73) | TACR1CACNA1FCHRM5CACNA1DCACNA1S | |
| SCHEMBL10380498 | 1.00 | TACR1 (0.73) | TACR1CACNA1FCHRM5CACNA1DCACNA1S | |
| SCHEMBL9322893 | 0.97 | TACR1 (0.74) | TACR1CACNA1FCHRM5CACNA1DCACNA1S | |
| SCHEMBL9322897 | 0.97 | TACR1 (0.74) | TACR1CACNA1FCHRM5CACNA1DCACNA1S | |
| SCHEMBL9322487 | 0.90 | TACR1 (0.72) | TACR1CACNA1FCHRM5CACNA1DCACNA1S | |
| SCHEMBL9322473 | 0.90 | TACR1 (0.72) | TACR1CACNA1FCHRM5CACNA1DCACNA1S | |
| SCHEMBL9322560 | 0.89 | TACR1 (0.80) | TACR1KCNK9KDM4EMEN1GMNN | |
| SCHEMBL9322552 | 0.89 | TACR1 (0.80) | TACR1KCNK9KDM4EMEN1GMNN | |
| SCHEMBL9322565 | 0.89 | TACR1 (0.80) | TACR1KCNK9KDM4EMEN1GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409931-B1 | QUINUCLIDINE THERAPEUTIC AGENTS | PFIZER (US) | 1994-02-16 | — | — | EP | disclosed |
| US-5162339-A | Substance P Antagonists, Gastrointestinal and Central Nervous System Disorders, Antiinflammatory Agents, Analgesics | PFIZER INC. (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0409931-A1 | QUINUCLIDINE THERAPEUTIC AGENTS. | PFIZER (US) | 1991-01-30 | — | — | EP | disclosed |
| WO-1990005729-A1 | QUINUCLIDINE THERAPEUTIC AGENTS | PFIZER INC. (US) | 1990-05-31 | — | — | WO | disclosed |
| WO-1990005525-A1 | QUINUCLIDINE DERIVATIVES AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1990-05-31 | — | — | WO | disclosed |