Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932170 | 0.77 | BACE1 (0.64) | BACE1BACE2KCNH2ALDH1A1 | |
| SCHEMBL932590 | 0.76 | BACE1 (0.66) | BACE1BACE2KCNH2 | |
| SCHEMBL931639 | 0.75 | BACE1 (1.00) | BACE1BACE2KCNH2 | |
| SCHEMBL931641 | 0.75 | BACE1 (1.00) | BACE1BACE2KCNH2 | |
| SCHEMBL932158 | 0.75 | BACE1 (0.59) | BACE1BACE2KCNH2 | |
| SCHEMBL943934 | 0.75 | BACE1 (0.67) | BACE1BACE2KCNH2 | |
| SCHEMBL932633 | 0.74 | BACE1 (0.60) | BACE1BACE2KCNH2 | |
| SCHEMBL933082 | 0.72 | BACE1 (0.67) | BACE1BACE2KCNH2 | |
| SCHEMBL931694 | 0.70 | BACE1 (0.73) | BACE1BACE2KCNH2 | |
| SCHEMBL932273 | 0.68 | BACE1 (0.56) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |