Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.71 |
| ▸ | PDE4A | P27815 | 5/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325314 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9325842 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9325318 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9325330 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9327384 | 0.86 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9327374 | 0.86 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9327377 | 0.86 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9167416 | 0.85 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7364134 | 0.85 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9062953 | 0.84 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362915-A | Inhibitors of enzymes/hydrolases; antiallergens, antiinflammatory agents | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-11-08 | — | — | US | claimed |
| EP-0523138-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1993-01-20 | — | — | EP | claimed |
| WO-1991015451-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1991-10-17 | — | — | WO | claimed |
| US-5362915-A | Inhibitors of enzymes/hydrolases; antiallergens, antiinflammatory agents | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-11-08 | — | — | US | disclosed |
| EP-0523138-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991015451-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1991-10-17 | — | — | WO | disclosed |