Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10602988 | 1.00 | TSHR (0.45) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL10913471 | 1.00 | TSHR (0.45) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL9326790 | 1.00 | TSHR (0.45) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL11101755 | 1.00 | TSHR (0.45) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL10590220 | 1.00 | TSHR (0.45) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL10508645 | 1.00 | TSHR (0.45) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL7278903 | 0.99 | TSHR (0.47) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL10605807 | 0.99 | TSHR (0.47) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL10343294 | 0.99 | TSHR (0.47) | TSHRALDH1A1CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL7276933 | 0.99 | TSHR (0.47) | TSHRALDH1A1CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243645-B1 | Compounds having a nootropic activity, agents containing them and their use in the treatment and prophylaxis of cognitive malfunctions | HOECHST AG (DE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0370378-A2 | Pyrrolidine-2-carboxylic-acid derivatives with a psychotropic activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0362555-A1 | Piperazinediones having psycotropic activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-11 | — | — | EP | disclosed |
| EP-0338508-A2 | Esters from amino-acids, their preparation process, drugs containing same and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-25 | — | — | EP | disclosed |
| EP-0243645-A2 | Compounds having a nootropic activity, agents containing them and their use in the treatment and prophylaxis of cognitive malfunctions | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-11-04 | — | — | EP | disclosed |