Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.80 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | PIM1 | P11309 | 2/20 | 0.65 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327162 | 1.00 | PPARG (0.80) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL9327176 | 0.88 | PPARG (0.64) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL1850981 | 0.87 | PPARG (0.73) | PPARGHPGDPIM1PIM2CISD1 | |
| SCHEMBL12520464 | 0.87 | PPARG (0.73) | PPARGHPGDPIM1PIM2CISD1 | |
| SCHEMBL1850984 | 0.87 | PPARG (0.73) | PPARGHPGDPIM1PIM2CISD1 | |
| SCHEMBL5111753 | 0.85 | PPARG (0.78) | PPARGHPGDPIM1PIM2CISD1 | |
| SCHEMBL1847035 | 0.85 | PPARG (0.78) | PPARGHPGDPIM1PIM2CISD1 | |
| SCHEMBL2260054 | 0.85 | PPARG (0.78) | PPARGHPGDPIM1PIM2CISD1 | |
| SCHEMBL6966749 | 0.85 | HPGD (0.69) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL6966747 | 0.85 | HPGD (0.69) | PPARGHPGDPIM1PIM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415605-B1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1994-03-02 | — | — | EP | disclosed |
| US-5132317-A | Thiazolidinediones, Hypoglycemia Agents | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| EP-0415605-A1 | Thiazolidinedione derivatives | Beecham Group p.l.c. (GB) | 1991-03-06 | — | — | EP | disclosed |