Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ramipril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 12/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | USP2 | O75604 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ramipril SCHEMBL7260219 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL7912384 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL13575807 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL9175613 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL8082369 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL683419 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL16059 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL13780690 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL5983968 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Ramipril SCHEMBL3533199 | 1.00 | ACE (1.00) | ACEMEN1KMT2ACYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243645-B1 | Compounds having a nootropic activity, agents containing them and their use in the treatment and prophylaxis of cognitive malfunctions | HOECHST AG (DE) | 1994-03-16 | — | — | EP | claimed |