Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.37 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9330383 | 0.98 | MEN1 (0.47) | MEN1KMT2AALDH1A1DRD2ADRA2A | |
| SCHEMBL21834896 | 0.92 | MEN1 (0.52) | MEN1KMT2AALDH1A1DRD2ADRA2A | |
| Bromide SCHEMBL29283498 | 0.89 | CYP1A2 (0.40) | MEN1KMT2AALDH1A1DRD2LMNA | |
| SCHEMBL927716 | 0.87 | HSD17B3 (0.40) | MEN1KMT2AALDH1A1THRBMAPT | |
| SCHEMBL27711046 | 0.86 | DRD3 (0.41) | MEN1KMT2AALDH1A1DRD2LMNA | |
| Hydrochloric Acid SCHEMBL30935728 | 0.85 | MEN1 (0.40) | MEN1KMT2AALDH1A1THRBMAPT | |
| Iodide SCHEMBL1780078 | 0.85 | HSD17B3 (0.39) | MEN1KMT2AALDH1A1THRBMAPT | |
| Iodide SCHEMBL2821259 | 0.85 | HSD17B3 (0.39) | MEN1KMT2AALDH1A1THRBMAPT | |
| Iodide SCHEMBL1780085 | 0.85 | HSD17B3 (0.39) | MEN1KMT2AALDH1A1THRBMAPT | |
| Fluoride SCHEMBL27681662 | 0.83 | DRD3 (0.39) | MEN1KMT2AALDH1A1DRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398358-B1 | Aluminum electroplating method | MITSUBISHI PETROCHEMICAL CO (JP) | 1994-03-09 | — | — | EP | claimed |
| US-5041194-A | Using low melting mixture of aluminum halide and onium halide of nitrogen-containing compound | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | claimed |
| EP-0398358-A2 | Aluminum electroplating method | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1990-11-22 | — | — | EP | claimed |
| EP-0398358-B1 | Aluminum electroplating method | MITSUBISHI PETROCHEMICAL CO (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5041194-A | Using low melting mixture of aluminum halide and onium halide of nitrogen-containing compound | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |