Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.84 |
| ▸ | TP53 | P04637 | 1/20 | 0.84 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.84 |
| ▸ | MAPT | P10636 | 1/20 | 0.84 |
| ▸ | HPGD | P15428 | 1/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.84 |
| ▸ | CYSLTR2 | Q9NS75 | 14/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 14/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9329427 | 1.00 | KDM4E (0.84) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9332008 | 0.97 | MAPT (0.81) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9332022 | 0.97 | MAPT (0.81) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9328901 | 0.95 | KDM4E (0.93) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9328916 | 0.95 | KDM4E (0.93) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9328909 | 0.92 | KDM4E (0.88) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9328894 | 0.92 | KDM4E (0.88) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| Cinalukast SCHEMBL37964 | 0.92 | KDM4E (1.00) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9328941 | 0.92 | KDM4E (0.97) | KDM4EMEN1ALDH1A1TP53ADRB1 | |
| SCHEMBL9330119 | 0.92 | KDM4E (0.97) | KDM4EMEN1ALDH1A1TP53ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355353-B1 | Cycloalkylthiazole derivatives | HOFFMANN LA ROCHE (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5001140-A | Cycloalkylthiazoles | HOFFMANN-LA ROCHE INC. (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0355353-A2 | Cycloalkylthiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-02-28 | — | — | EP | disclosed |