SCHEMBL9329478

SCHEMBL9329478

FC1(F)C(Cl)=C(Cl)C1(Cl)Cl

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
THRB P10828 1/20 0.32
RECQL P46063 1/20 0.32
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
HIF1A Q16665 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5677374 0.80
SCHEMBL5804835 0.76 MEN1 (0.31) MEN1THRBRECQLKMT2AALDH1A1
SCHEMBL7637768 0.74 MEN1 (0.33) MEN1THRBRECQLKMT2AALDH1A1
SCHEMBL9327898 0.74 MEN1 (0.33) MEN1THRBRECQLKMT2AALDH1A1
SCHEMBL5678547 0.74 MEN1 (0.33) MEN1THRBRECQLKMT2AALDH1A1
SCHEMBL2816037 0.72
SCHEMBL9328074 0.71 MEN1 (0.32) MEN1THRBRECQLKMT2AALDH1A1
SCHEMBL8176504 0.71 MEN1 (0.43) MEN1THRBRECQLKMT2AALDH1A1
SCHEMBL1763878 0.69
SCHEMBL1995973 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111039746-B Method for synthesizing 4, 4-difluorocyclobutene by gas phase catalysis 中国矿业大学(北京) 2021-03-23 CN claimed
CN-111039746-A Method for synthesizing 4, 4-difluorocyclobutene by gas phase catalysis 中国矿业大学(北京) 2020-04-21 CN claimed
CN-111039746-B Method for synthesizing 4, 4-difluorocyclobutene by gas phase catalysis 中国矿业大学(北京) 2021-03-23 CN disclosed
CN-111039746-B Method for synthesizing 4, 4-difluorocyclobutene by gas phase catalysis 中国矿业大学(北京) 2021-03-23 CN disclosed
CN-111039746-A Method for synthesizing 4, 4-difluorocyclobutene by gas phase catalysis 中国矿业大学(北京) 2020-04-21 CN disclosed
CN-111039746-A Method for synthesizing 4, 4-difluorocyclobutene by gas phase catalysis 中国矿业大学(北京) 2020-04-21 CN disclosed
EP-0425887-B1 Process for halogen-fluor exchange in organic compounds and catalysts therefor BAYER AG (DE) 1994-03-23 EP disclosed
US-5233105-A Fluorination using hydrogen fluoride BAYER AKTIENGESELLSCHAFT (DE) 1993-08-03 US disclosed