Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 3/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 10/20 | 0.32 |
| ▸ | JAK1 | P23458 | 6/20 | 0.32 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17316683 | 0.89 | JAK3 (0.34) | JAK3JAK1JAK2EGLN2 | |
| SCHEMBL933998 | 0.80 | POLB (0.42) | NMT1 | |
| SCHEMBL1306110 | 0.74 | JAK3 (0.45) | FLT3IRAK4JAK3JAK1JAK2 | |
| SCHEMBL29591041 | 0.74 | JAK3 (0.45) | FLT3IRAK4JAK3JAK1JAK2 | |
| Hydrochloric Acid SCHEMBL4133640 | 0.73 | JAK3 (0.44) | FLT3IRAK4JAK3JAK1JAK2 | |
| SCHEMBL25387189 | 0.72 | FLT3 (0.50) | FLT3IRAK4NOS3NOS1NOS2 | |
| SCHEMBL31283023 | 0.72 | FLT3 (0.50) | FLT3IRAK4NOS3NOS1NOS2 | |
| SCHEMBL182698 | 0.69 | — | — | |
| SCHEMBL105810 | 0.68 | HRH4 (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL17316868 | 0.68 | BRD4 (0.37) | EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451802-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | Pathway Therapeutics, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005119-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2011-01-13 | — | — | WO | disclosed |