Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932672 | 1.00 | KDM1A (0.44) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| SCHEMBL29404068 | 1.00 | KDM1A (0.44) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| SCHEMBL22917359 | 1.00 | KDM1A (0.44) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL15017147 | 0.98 | KDM1A (0.43) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL15017843 | 0.98 | KDM1A (0.43) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL29526160 | 0.98 | KDM1A (0.43) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL15017144 | 0.98 | KDM1A (0.43) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| SCHEMBL28286568 | 0.97 | KCNH2 (0.43) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| SCHEMBL1765273 | 0.95 | KDM1A (0.43) | KDM1AKDM1BMEN1KMT2AKCNH2 | |
| Oxalic Acid SCHEMBL28871386 | 0.91 | HCAR2 (0.40) | KDM1AKDM1BMEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 476 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115872905-B | Preparation method of larotinib intermediate | 凯特立斯（深圳）科技有限公司 | 2024-08-09 | — | — | CN | claimed |
| CN-114478345-B | Preparation method of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 中瀚(齐河县)生物医药科技有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-118109434-A | Transaminase and its application in synthesizing (R) -2- (2, 5-difluorophenyl) pyrrolidine | 上海飞腾医药科技有限公司 | 2024-05-31 | — | — | CN | claimed |
| CN-118006577-A | Transaminase and application thereof in synthesis of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 上海飞腾医药科技有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-117965480-A | Recombinant aminotransferase and application thereof in synthesis of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 上海飞腾医药科技有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-114774383-B | Imine reductase mutant and application thereof in catalytic synthesis of chiral 2-arylpyrrolidine | 安徽趣酶生物科技有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-114507172-B | Synthesis method of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 四川依维欣医药科技有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-110283858-B | Method for preparing (S) -2- (2, 5-difluorophenyl) pyrrolidine by biocatalysis | 尚科生物医药（上海）有限公司 | 2024-01-26 | — | — | CN | claimed |
| CN-114075557-B | Recombinant aminotransferase and its use in the synthesis of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 上海飞腾医药科技有限公司 | 2023-12-22 | — | — | CN | claimed |
| CN-117025699-A | Synthesis method of larotinib key intermediate | 泰州学院 | 2023-11-10 | — | — | CN | claimed |
| CN-111138333-A | Preparation method of (R) -2- (2, 5-difluorophenyl) -pyrrolidine | 上海复星星泰医药科技有限公司 | 2020-05-12 | — | — | CN | claimed |
| CN-111057729-A | (R) -2- (2, 5-difluorophenyl) pyrrolidine and preparation method and application thereof | 上海弈柯莱生物医药科技有限公司 | 2020-04-24 | — | — | CN | claimed |
| CN-110283858-A | The method that biocatalysis prepares (S) -2- (2,5- difluorophenyl) pyrrolidines | 尚科生物医药（上海）有限公司 | 2019-09-27 | — | — | CN | claimed |
| CN-107286070-B | Synthesis method and intermediate of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 浙江师范大学 | 2019-07-16 | — | — | CN | claimed |
| CN-109824566-A | The synthetic method of one kind (R) -2- (2,5- difluorophenyl) pyrrolidines | 浙江师范大学 | 2019-05-31 | — | — | CN | claimed |
| CN-109593802-A | The preparation method of one kind (R) -2- (2,5- difluorophenyl) pyrrolidines or its salt | 上海健康医学院 | 2019-04-09 | — | — | CN | claimed |
| CN-109593803-A | (R) preparation method of -2- (2,5- difluorophenyl) pyrrolidines or its salt | 上海健康医学院 | 2019-04-09 | — | — | CN | claimed |
| CN-108484361-A | (S) the chloro- 1- of -4- (2,5)-difluorophenyl butyl- 1- alcohol and its preparation method and application | 上海弈柯莱生物医药科技有限公司 | 2018-09-04 | — | — | CN | claimed |
| CN-108218754-A | A kind of preparation method of 2- (2,5- difluorophenyls) pyrrolidines | 广东赛烽医药科技有限公司 | 2018-06-29 | — | — | CN | claimed |
| CN-107286070-A | Synthesis method and intermediate of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 浙江师范大学 | 2017-10-24 | — | — | CN | claimed |