⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674201 | 0.80 | — | — | |
| SCHEMBL18281303 | 0.75 | — | — | |
| SCHEMBL7453607 | 0.72 | — | — | |
| SCHEMBL296651 | 0.71 | — | — | |
| SCHEMBL6010298 | 0.70 | — | — | |
| SCHEMBL8917855 | 0.69 | — | — | |
| SCHEMBL1007421 | 0.68 | — | — | |
| SCHEMBL15109751 | 0.67 | — | — | |
| SCHEMBL1431147 | 0.65 | — | — | |
| SCHEMBL17157487 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 409 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112194660-B | PDE2 inhibitor phenyl pyrazolopyrimidine compound and preparation method thereof | 常州大学 | 2021-12-03 | — | — | CN | claimed |
| CN-112194660-A | PDE2 inhibitor phenyl pyrazolopyrimidine compound and preparation method thereof | 常州大学 | 2021-01-08 | — | — | CN | claimed |
| CN-110003214-A | Substituted pyrazolo [1,5-a] pyrimidine compound as TRK kinase inhibitor | 阵列生物制药公司 | 2019-07-12 | — | — | CN | claimed |
| CN-108997340-A | Synthetic method of 5-bromo-7-azaindole | 山东轩德医药科技有限公司 | 2018-12-14 | — | — | CN | claimed |
| CN-107531666-A | The inhibitor of GDF 8 | 里格尔药品股份有限公司 | 2018-01-02 | — | — | CN | claimed |
| CN-106834081-A | A kind of vertical purple potato pears compound fruit vinegar fermentation tank control system and its method of work | 徐州工程学院 | 2017-06-13 | — | — | CN | claimed |
| WO-2016191935-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | claimed |
| CN-106008519-A | Synthesis method of 5-(4-fluorophenyl)-N-morpholinyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidyl-3-amide | 重庆医药高等专科学校 | 2016-10-12 | — | — | CN | claimed |
| CN-106008518-A | Synthesis method of 5-(4-fluorophenyl)-N-(4-chlorophenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-3-amide | 重庆医药高等专科学校 | 2016-10-12 | — | — | CN | claimed |
| CN-106008520-A | Synthesis method of 5-arylpyrazolopyrimidine derivatives | 重庆医药高等专科学校 | 2016-10-12 | — | — | CN | claimed |
| EP-1761541-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| CN-1906197-A | Two-phase method for the synthesis of selected pyrazolopyrimidines | MALLINCKRODT INC (US) | 2007-01-31 | — | — | CN | claimed |
| CN-1882591-A | 5, 7-diaminopyrazolo [4, 3-d ] pyrimidines with PDE-5 inhibiting activity | PFIZER LTD (US) | 2006-12-20 | — | — | CN | claimed |
| CN-1826345-A | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands | NEUROGEN CORP A CORP OF THE ST (US) | 2006-08-30 | — | — | CN | claimed |
| WO-2006084634-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-17 | — | — | WO | claimed |
| CN-1243753-C | Substituted 3, 4-dihydro-pyrimido [1, 2-a ] pyrimidines and 3, 4-dihydro-pyrazino [1, 2-a ] pyrimidines | GRUENENTHAL GMBH (DE) | 2006-03-01 | — | — | CN | claimed |
| WO-2005123738-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-29 | — | — | WO | claimed |
| CN-1507447-A | Substituted pyrazolopyrimidines and thiazolopyrimidines | — | 2004-06-23 | — | — | CN | claimed |
| CN-1469879-A | Substituted 3,4-dihydro-pyrimido[1,2-A] pyrimidines and 3,4-dihydropyrazino [1,2-A] pyrimidines | — | 2004-01-21 | — | — | CN | claimed |
| EP-0208846-B1 | [7-(3-Disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID CO (US) | 1993-11-18 | — | — | EP | claimed |