Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9432520 | 0.85 | PDE3B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9681961 | 0.84 | PDE3B (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9846132 | 0.76 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL24551105 | 0.75 | GRIN2D (0.43) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9456060 | 0.75 | GRIN2D (0.39) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9846307 | 0.73 | GRIN2D (0.42) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9431837 | 0.71 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL22867594 | 0.71 | DPYD (0.44) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9274056 | 0.71 | GAA (0.65) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9265798 | 0.71 | KDM4E (0.53) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364776-A | Biosynthesis, enzyme inhibitors, treatment of AIDS | MERCK & CO., INC. (US) | 1994-11-15 | — | — | US | disclosed |
| US-5308854-A | 2-benzoxazolylalkyl substituted pyridin-2(1H)(thi)ones; AIDS | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | disclosed |
| US-5215900-A | Biosynthesis a culture product utilizing as enzyme inhibitor in treatment of immune deficiency syndrome | MERCK & CO., INC. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5200329-A | An Isolating Compound Which is Useful in the Prevention or Tre atment of HIV Infection and the Treatment of AIDS | MERCK & CO., INC. (US) | 1993-04-06 | — | — | US | disclosed |
| US-5169769-A | Aerobic culture product | MERCK & CO., INC. (US) | 1992-12-08 | — | — | US | disclosed |
| CN-1062138-A | The synergy of HIV reverse transcriptase inhibitors | MERCK & CO INC (US) | 1992-06-24 | — | — | CN | disclosed |
| EP-0484071-A2 | Synergism of HIV reverse transcriptase inhibitors | MERCK & CO. INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0462808-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |